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Therapies for pain conditions like fibromyalgia provide clues for helping those with long COVID.

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Michigan Medicine resource for patients with post-acute sequelae of COVID-19, also known as long COVID.

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Welcome to Health Lab, your destination for news and stories about the future of healthcare. Today: Managing Chronic Pain for Patients with Long COVID. Long COVID-19 is linked to chronic pain conditions. Therapies for pain conditions like fibromyalgia provide clues for helping those with long COVID.

Many patients continue to struggle in the wake of the pandemic as they grapple with ongoing symptoms triggered by COVID-19 infection, a condition commonly known as long COVID. However, the onset of symptoms such as brain fog, fatigue, headache, and other types of pain is not unique to COVID infection, according to a new U-M study.

What’s more, these patients may be helped by capitalizing on the body of research around chronic overlapping pain conditions (COPCs), such as fibromyalgia, migraine, low back pain and others.

The work, led by Rachel Bergmans, Ph.D., of the Department of Anesthesiology and a team from the Chronic Pain & Fatigue Research Center at Michigan Medicine, sought to identify whether long COVID was distinct from other pain syndromes and whether chronic pain conditions increased the risk of features of long COVID. 

“We hypothesized we’d see an increase in pain and fatigue because it’s something we’ve seen in the past with other infectious diseases, like the SARS outbreak in 2002,” said Bergmans.

To test this, they identified health records of three subsets of patients from throughout the United States: people with COVID, people with influenza, and people without an infection. They then compared the likelihood of receiving a long COVID diagnosis in people with COPCs vs. those without pain conditions. 

They discovered that having a COPC increased the risk for long COVID features in each group and had a similar effect size to sex or being hospitalized for COVID, known risk factors for long COVID. Interestingly, those with influenza were even more likely than those with COVID infection to have features of long COVID. Furthermore, long COVID features were found in a little over 24% of people with COPCs even in the absence of infection.

What could be going on? Bergmans noted that a relatively recently defined type of pain known as nociplastic pain — pain due to heightened sensitization in the central nervous system -- might help explain some of the findings. 

“A big predictor of future pain is having had pain in the past,” she said. “With nociplastic pain, some people have what you might call a pain setting turned up in their central nervous system. There’s evidence showing that infections, trauma, and stress can be a trigger for nociplastic pain features and related symptoms.” 

Nociplastic pain often co-occurs with cognitive dysfunction and other symptoms related to long COVID, she added. The good news is the existing body of evidence around the treatment of chronic pain could offer patients with long COVID a basis for management as more research into the condition continues. For example, Michigan Medicine developed a resource, which will be linked in the show notes, for patients with post-acute sequelae of COVID-19, providing advice for navigating this often-misunderstood condition.

“The pandemic brought awareness to how disabling these symptoms can be and the burden they have on people’s lives,” said Bergmans.

For more on this story and for others like it, visit michiganmedicine.org/health-lab. Health Lab is a part of the Michigan Medicine Podcast Network, and is produced by the Michigan Medicine Department of Communication. You can subscribe to Health Lab wherever you listen to podcasts.