Drug used for alcoholism shows potential for stopping inflammatory disease

A study reveals how the drug disulfiram, which blocks the liver’s ability to process alcohol, can also stop inflammation

5:00 AM

Author | Kelly Malcom

pill bottle spilling yellow blue
Jacob Dwyer, Justine Ross, Michigan Medicine

Could a drug used to treat alcoholism also treat Alzheimer’s? 

A recent University of Michigan study reveals how the drug disulfiram, which blocks the liver’s ability to process alcohol resulting in discomfort and a severe hangover, also shuts down an inflammatory complex known as NLRP3. 

This inflammatory process is suspected to lead to a number of other common diseases, including Alzheimer’s and diabetes.

The discovery was accidental, said lead author Jie Xu, Ph.D., of the Department of Pathology at the University of Michigan Medical School, who works in the laboratory of Gabriel Nuñez, M.D., and was researching drugs that inhibit a protein activated downstream from the NLRP3 inflammasome.

An inflammasome is a type of sensor designed to respond to specific threats and upon activation induces inflammation.

Xu, along with collaborators Nuñez, and Joseph Pickard, Ph.D., found that disulfiram blocks a process called palmitoylation, which adds a lipid onto the NLRP3 protein required to shuttle it within the cell in order to activate it. 

To further support their finding, they stimulated the inflammatory process in mice using a bacterial toxin and found that administering disulfiram reduced NLRP3-mediated inflammation. 

Said Xu, "This FDA-approved drug is considered safe, so it may be repurposed. Alternatively, using new information about its mechanism of action, chemists could develop derivatives that are even more specific to the NLRP3 inflammasome."

Paper cited: “FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation,” Cell Reports. DOI: 10.1016/j.celrep.2024.114609


More Articles About: Basic Science and Laboratory Research Alzheimer's Disease Diabetes
Health Lab word mark overlaying blue cells
Health Lab

Explore a variety of health care news & stories by visiting the Health Lab home page for more articles.

Media Contact Public Relations

Department of Communication at Michigan Medicine

[email protected]

734-764-2220

Stay Informed

Want top health & research news weekly? Sign up for Health Lab’s newsletters today!

Subscribe
Featured News & Stories Microscope
Health Lab
Nerve damage reduced in prediabetic mice with diet, exercise
A low calorie diet and high intensity exercise can reduce nerve damage in prediabetic mice, according to a Michigan Medicine study.
cell formation in grey and then two circles highlighed blue and one red
Health Lab
The solution to death from a fentanyl overdose could lie in its chemical structure
University of Michigan researchers may have found that the solution to prevent people from dying from a fentanyl overdose may be found within fentanyl's own chemistry.
close up of orange and purple squiggle-looking cells merging and a little green in the middle
Health Lab
Researchers find metabolic mechanism that blocks immune response, immunotherapy in cancer
New research has discovered why some cancers don’t respond to immunotherapy treatment: A metabolite transporter within the tumor microenvironment blocks a key type of tumor cell death integral to immune response.
older woman lying in bed
Health Lab
Sleep apnea contributes to dementia in older adults, especially women
Obstructive sleep apnea, a common and underdiagnosed sleep disorder, contributes to dementia in older adults — particularly women, a study suggests.
Health Lab Podcast in brackets with a background with a dark blue translucent layers over cells
Health Lab Podcast
Growing numbers of diabetic retinopathy in kids
Research highlights alarming rates of diabetic retinopathy; an ophthalmologist shares what to know.
blurred front door exit with people walking through in blue see through doors
Health Lab
Medicare has a revolving door, study suggests
Medicare Advantage vs traditional Medicare is an annual Open Enrollment decision, and a new study looks at how many older adults revolve between the two.