Alla Karnovsky, PhD
Program Director
Associate Professor of Computational Medicine and Bioinformatics
[email protected]

Available to mentor

Alla Karnovsky, PhD
Associate Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    My background includes Ph.D. in cell and developmental biology (Russian Academy of Sciences), postdoctoral work at the University of Colorado at Boulder and nine years of bioinformatics work in Pharmaceutical industry (at Pharmacia and at Pfizer). I have broad experience in identification and validation of therapeutic targets in variety of disease areas including antibacterials, CNS and dermatology. I am also interested in structural aspects of drug/target interactions and the integration of chemical and genomic domains.

    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    My research interests involve the analysis of high throughout omics data, focusing primarily on metabolomics, and the development of computational methods and tools for the analysis and integration of metabolomics data with other types of genomic data. I am also interested in biomedical ontologies and one of my current projects involves the development of Informed Consent Ontology.

    Recent Publications See All Publications
    • Journal Article
      Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis.
      Zhao Y, Li X, Wang K, Iyer G, Sakowski SA, Zhao L, Teener S, Bakulski KM, Dou JF, Traynor BJ, Karnovsky A, Batterman SA, Feldman EL, Sartor MA, Goutman SA. EBioMedicine, 2024 Nov; 109: 105383 DOI:10.1016/j.ebiom.2024.105383
      PMID: 39369616
    • Journal Article
      Metabolomic Alterations Associated with Phthalate Exposures among Pregnant Women in Puerto Rico.
      Siwakoti RC, Iyer G, Banker M, Rosario Z, Vélez-Vega CM, Alshawabkeh A, Cordero JF, Karnovsky A, Meeker JD, Watkins DJ. Environ Sci Technol, 2024 Oct 15; 58 (41): 18076 - 18087. DOI:10.1021/acs.est.4c03006
      PMID: 39353139
    • Journal Article
      metabCombiner 2.0: Disparate Multi-Dataset Feature Alignment for LC-MS Metabolomics.
      Habra H, Meijer JL, Shen T, Fiehn O, Gaul DA, Fernández FM, Rempfert KR, Metz TO, Peterson KE, Evans CR, Karnovsky A. Metabolites, 2024 Feb 15; 14 (2): DOI:10.3390/metabo14020125
      PMID: 38393017
    • Journal Article
      CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data.
      Iyer G, Brandenburg M, Patsalis C, Michailidis G, Karnovsky A. J Vis Exp, 2023 Nov 10; (201): DOI:10.3791/65512
      PMID: 38009735
    • Journal Article
      Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-l-cysteine Stimulates Changes in Energy Metabolites and Amino Acids in the BeWo Human Placental Trophoblast Model during Syncytialization.
      Su AL, Harris SM, Elkin ER, Karnovsky A, Colacino J, Loch-Caruso RK. Chem Res Toxicol, 2023 Jun 19; 36 (6): 882 - 899. DOI:10.1021/acs.chemrestox.3c00007
      PMID: 37162359
    • Journal Article
      Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response.
      Jennaro TS, Puskarich MA, Evans CR, Karnovsky A, Flott TL, McLellan LA, Jones AE, Stringer KA. Crit Care Explor, 2023 Apr; 5 (4): e0881 DOI:10.1097/CCE.0000000000000881
      PMID: 36998529
    • Journal Article
      Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles.
      Goutman SA, Boss J, Iyer G, Habra H, Savelieff MG, Karnovsky A, Mukherjee B, Feldman EL. Muscle Nerve, 2023 Mar; 67 (3): 208 - 216. DOI:10.1002/mus.27744
      PMID: 36321729
    • Proceeding / Abstract / Poster
      Metabolomic Signatures Associated With Weight Gain and Psychosis Spectrum Diagnoses
      Lee J, Costa-Dookhan K, MacKenzie N, Treen QC, Chintoh A, Remington G, Mueller DJ, Sockalingam S, Gerretsen P, Sanches M, Karnovsky A, Stringer K, Ellingrod V, Tso I, Taylor S, Agarwal SM, Hahn M, Ward K. BIOLOGICAL PSYCHIATRY, 2023 93 (9): S99 - S99.
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